This is a clinical, randomized and double blind trial which aims to determine the effect effect of vitamin D supplementation on metabolic, oxidant, inflammatory indices, sirtuin-1 and irisin in type2 diabetic patients
After obtaining the informed consents, the researchers invite 90 male and female suffering from type2 diabetes aged 25 to 65 years in accordance with the inclusion criteria (serum 25 hydroxy vitaminD3 less than 30 ng/ ml, body mass index between 25 up to 35 kg/m² and HbA1c level of less than 8.5%) and exclusion criteria (insulin, pregnancy and lactation; the subjects' levels of triglyceride more than 250 mg/dl and cholesterol more than 300 mg/dl), they are invited from Besat Diabetic Clinic, Rasht and randomly divided into two intervention and placebo groups. The intervention group will use pearl of 50,000IU of vitaminD3 every week and the placebo group will have edible paraffin similar to vitaminD3 for 8 weeks.
At the beginning and end of the study, metabolic (Fasting blood sugar and glycosylated hemoglobin, reactive C peptide and lipid profile ), oxidant (red blood cells Gpx and SOD), inflammatory (hsCRP, ESR) indices, serum levels of 25 hydroxyvitaminD3, sirtuin-1 and irisin, Insulin sensitivity and insulin resistance will be measured.