The aim of the present study is to compare the efficacy of short message text (interactive and non-interactive) on treatment adherence, severity of depression and spiritual health in patients with major depression. Study is an quasi experimental, non-blinded, single center, with control group. The study population is eligible depressed patients referred to Hajar Hospital’s Psychiatry Clinic in Shahrekord. Inclusion criteria are major depression according to diagnosis of a psychiatrist and DSM-IV-TR criteria, being literate, ability to work with cell phone and reading and writing text message and exclusion criteria are refusing to participate in the study and lack of cooperation during the intervention. The study sample consists of 90 eligible depressed patients. These patients will be allocated to three groups (30 in each groups): interactive short message, non-interactive short message, and without short message. In non-interactive message group, the patients would receive every day hopeful messages derived from traditions and elite, and tips about side effects, percussion, and medication reminder for 6 weeks. In the interactive message group, the same messages would be sent in an interactive form in a similar way. Spiritual well- being, depression severity, and treatment adherence of the patients would be assessed by Paloutzian and Ellison spiritual well-being scale, Beck Depression Inventory, and treatment adherence researcher-made questionnaire at beginning and the end of intervention.