Objectives: Determination of the effect of Hatha Yoga on the quality of life in hemodialysis patients. Design: This study is a clinical trial that performed for an experimental and control groups. Setting and conduct: researcher does the sampling based on objective among all the patients who are admitted to the Hemodialysis Department of 5 Azar hospital in Gorgan with the Population size of 174 people, (89 men and 85 women). The sample size is 16 people, so 32 patients are assigned and placed in experimental and controls groups of 16 people, randomly. For adjustment of gender variable in sampling based on objective, 16 female patients from women group and 16 male patients from men group of research community selected, Then based on a random numbers table, from each group of 16 male and female, 8 female and 8 male patient placed in experimental group and 8 female and 8 male patient in control group, randomly. Thus 2 experimental and control groups are selected and experimental group similar to the control group includes 8 male and 8 female who have all the Inclusion criteria and the only difference is Hatha Yoga intervention that is done for the experimental group. Data collection tool is a questionnaire consists of two parts include demographic information and quality of life questionnaire SF36. First, the quality of life of patients in both groups checked. During the 12 weeks, each week two times, Patients in the experimental group will participate in the training sessions of Hatha yoga which will be held in the Sports Hall of Hospital by master trainer who has a history of training. After 12 weeks, the patients' life quality in groups will re-examine and compare. Participants including major eligibility criteria: 3 months have passed since the first turn of hemodialysis of patients. Be interested in participating in the study, filling out the questionnaire and attending the Hatha Yoga exercise classes. Not being membership of yoga classes. Participants excluding major eligibility criteria: Absence of more than 4 sessions of 24 session training class, Withdrawal or reluctance to exercise during the study. Interventions: in 12 weeks, 2 times each week (A total of 24 sessions), Patients in the experimental group will participate in the training sessions of Hatha yoga which will be held in the Sports Hall of Hospital by master trainer who has a history of training. Training sessions of male and female patients will be separate and held with a separate instructor. The main outcome variable: Quality of life of Hemodialysis patients.