The evaluation of Cerebrolysin effect on cognitive and verbal aspects of children suffering from autism spectrum disorder

Objective : Determination of Cerebrolysin effects on cognitive and verbal aspects of children suffering from autism spectrum disorder Design: Thirty six children ranging in age from 3 to 10 year-old children suffering from Autism spectrum disorder referred to pediatric neurologic clinic in pediatric center of excellence from August 2014 to February 2015 are included in this study. No blinding and randomization were done. Setting and Conduct: Childhood Autistic Rating Scale (CARS) questionnaire includes 15 sections. It evaluates cognitive and verbal aspects of Autistic children. Patients receive a grade from 1 to 4 in each of 15 sections. Patients are evaluated again by CARS questionnaire one month after completing the treatment. At the end, according to changes in grades in second evaluation, the efficacy of medication will be evaluated in four aspects of so called questionnaire. Participants including major eligible criteria: selected children are required not to receive any kinds of new medications during the recent three months ago and having neither past history of seizure nor intra-cerebral hemorrhage. Intervention: Cerebrolysin is prescribed by a supervisor, injected intramuscularly, 1cc in 3 days a week in first month of study, followed by gradual decrease in dose during the second month ( two injections in first week, two injection in second week, one injection in third week and, finally one injection in forth week). Main outcome measures: -verbal and non-verbal communication, emotional response, relationship to people

Vice chancellor for research, Tehran University of Medical Sciences