Thyme combined effect of triple therapy regimen compared with the standard regimen alone in eradication of Helicobacter pylori infection in patients who referred with upper gastrointestinal symptoms.

Objectives According to the high incidence of Helicobacter pylori infection in Iran and antimicrobial effects of thyme, we aim to compare the rate of Helicobacter pylori eradication by standard regime and standard therapeutic regime plus thyme. Design This study is a not blinded clinical trial and patients after informed consent enroll in study and divide in two groups for interventions. Setting and conduct All subjects who fulfill our inclusion criteria randomly divide in two groups (30 patients in each group) and therapeutic interventions will perform. Participants including main inclusion criteria Patients with gastrointestinal symptoms who have upper gastrointestinal endoscopy with a positive urea breath test will enroll in study. Intervention Intervention group will receive a regimen including pantoprazole, amoxicillin, clarithromycin and thyme (gastrolite) and the control group will receive pantoprazole, amoxicillin, clarithromycin and placebo (instead of thyme). The dose of the prescribed drugs are as follows: pantoprazole tablets 40 mg two times per day, amoxicillin 1 g capsule two times per day, clarithromycin 500 mg capsules two times per day and thyme as capsule (gastrolite) every 8 hours and in the control group a placebo with similar appearance for 2 weeks. Then the pantoprazole (40 mg daily) continue for another two weeks, then after a two weeks washout period to avoid from false negative response, urea breath test is performed and results will be recorded. Main outcome variables Helicobacter pylori eradication (based on urea breath test)

Vice Chancellor for Research and Technology of Semnan University of Medical Sciences