Impact of subcutaneous injection of 0.5% bupivacaine into skin incision on hemodynamic changes during operation in lower abdominal surgeries.

Objectives We aimed to determine the impact of subcutaneous injection of 0.5% bupivacaine into the surgical incision on hemodynamic changes during operation in the lower abdominal surgeries. Design In a randomized, case-control clinical trial, phase 3, forty-four patients who were candidate for lower abdominal surgery at sensory level below the umbilicus (anesthesia at T10 level) and referred for surgery to Kowsar hospital enrolled in study. Setting and conduct Participating patients were randomly assigned to the intervention or control groups by randomization blocks if they fulfilled inclusion criteria, then interventions were done. Participants including major eligibility criteria Patients in class I and II based on American Surgery Association (ASA) classification who candidate for lower abdominal surgery at sensory level below the umbilicus (anesthesia at T10 level) including inguinal hernia, varicoceles and appendectomy, enrolled in study. All patients with underlying conditions including heart disease, thyroid disorders, uncontrolled diabetes and age more than 65 years excluded from study. Intervention In the case group, bupivacaine was subcutaneously injected into the surgical incision and surgery performed under general anesthesia. In the control group normal saline was subcutaneously injected into the surgical incision as placebo and surgery was done under general anesthesia. Main outcome measures Mean arterial blood pressure and heart rate.

Vice chancellor for research, Semnan University of Medical Sciences