Compare the efficacy of two protocols of ovarian stimulation using Gonal-F and Luveris in women with hypogonadotropic hypogonadism undergoing assisted reproductive technique Compare the efficacy of two protocols of ovarian stimulation using Gonal-F and Luveris in women with hypogonadotropic hypogonadism undergoing assisted reproductive technique

This study compares the efficacy of two protocols of ovarian stimulation using Gonal-F and Luveris in women with hypogonadotropic hypogonadism undergoing assisted reproductive technique. In this single blind randomized clinical trial, women with a clinical history of hypogonadotrophic hypogonadism who stopped any treatment with gonadotrophins >1 month before study, with a negative progesterone challenge test, low serum gonadotrophins (LH and FSH less than 5.0 IU/l) and oestradiol (less than 100 pg/ml) and normal serum concentrations of thyroid stimulating hormone (TSH), testosterone and prolactin within 6 months before the start of treatment are enrolled. Other causes of infertility are excluded from the study. In this study 90 infertile women with hypothalamic amenorrhea undergoing assisted reproductive technique in the Royan Institute are studied. All patients receive treatment with Gonal-F (rFSH) (starting dose 150 IU/day and from day 2-3 according to the ovarian response) and Luveris (rLH) (fixed dose of 75 IU/day). When at least one follicle reaches 14 mm in diameter, 4mg/day oestradiol is administered and patients are randomly divided into two groups: Luveris alone (intervention group) and continued treatment with both drugs Gonal-F and Luveris (control group). At the end, the number and size of ovarian follicles, endometrial thickness on the day of injection of hCG and the number of oocytes retrieved will be compared between the two groups.

Royan Institute