The aim of this randomized controlled clinical trial is to compare the efficacy of intramuscular morphine and morphine suppository in relieving pain of patients with renal colic. The study will be done on 18 to 55 years old patients with renal colic who will come to the emergency department of Kowsar hospital in Semnan, Iran. Patients with unilateral acute flank or abdominal colicky pain will be included in the study that in evaluation of the patient with ultrasonography, CT scan or intravenous pyelography presence of the urinary stone will be approved or the patient will pass the stone. Exclusion criteria will be sensitivity to morphine, addiction, existence of fever, impaired hepatic or renal function, heart or respiratory failure, suspected to peritonitis, pregnancy and receiving analgesic within 6 hours before admission. Sample size will be 84 patients that will be divided with randomized permuted blocks into two groups (42 in each group). For control of pain one group will receive 10 mg intramuscular morphine and the other group 10 mg morphine suppository. First, the intensity of patient pain will be assessed based on VAS (visual analogue scale) and after control of blood pressure, pulse and respiratory rate and recording them in the questionnaire, they will be treated with morphine suppository or intramuscular morphine. In 15, 30 and 60 minutes intervals after drug prescription, reevaluation according to pain relief based on VAS as well as morphine side effects will be done. Demographic data, VAS points and drug side effects will be recorded in the questionnaire.