Objectives:To determine the effect of erythromycin on the establishment of feeding in infants under 32 weeks gestation.
Design:randomized, double-blind, clinical trial; Study population: 40 preterm infants under 32 weeks gestation hospitalized in the neonatal intensive care unit with a diagnosis of dietary intolerance randomly divided into two groups; Study type: one center; Study phase: Phase II.
Setting and conduct: The first group (n=20) that Erythromycin ethyl succinate oral (10 mg per kg every six hours to two days, followed by 4 mg per kg every six hours to 5 days) and group II (n=20) treated with normal saline will receive the same dose and instructions. The duration of treatment for both groups will be equivalent to one week.
Participants: Inclusion criteria : Infants less than 32 weeks gestational age or weighting less than 1800 g and the minimum age is 5 days after birth and are clinically stable economical state (normal blood pressure Episodes of bradycardia and hypoxemia not) feeding intolerance for less than 75 milli liters per kilogram per day 14 days remain gay or gastric material by more than 50% of 3 hours, which occurred at least two times during the 24 hour period or more than 30% of gastric residues 3 hours ago happened at least three times.
Exclusion criteria :
lethal congenital malformations congenital or chromosomal disorders, cyanotic heart disease, diseases of the gastrointestinal tract obstruction (mal rotation, atresia and Omphalocele, etc.), gastrointestinal surgeries in 14 days ago, NEC suspected or confirmed in the last 7 days, definite or clinical sepsis, metabolic disorders or electrolytic , and treatment with any of the following medications at the onset of feeding intolerance fentanyl , indomethacin , pancuronioum.
Interventions : The use of erythromycin ethylene succinate in the study group.
Main outcome: Infant can tolerate 150 milliliter per kilogram in at least 24 hours in one day; side effects of treatment include diarrhea, vomiting, pyloric stenosis and evidence of necrotizing enterocolitis; the length of stay in ICU and hospital.