Abstract :
The purpose was to compare the effect of probiotic with polyethylene glycol and polyethylene glycol alone for the treatment of functional constipation in children.
Design: In this study children with functional constipation randomly allocated into two groups. To the first group was given polyethylene glycol and second group was given probiotic and polyethylene glycol. After 6 weeks, probiotic was added to group1 and removed from group2 medication. The study fallowed for more six weeks. The results of 4th week were compared with 1th week, and the results of 10th week were compared with 7th week in each groups. The data of 4th and 10th weeks were also compared between both groups.
How do: Number of 80 children with functional constipation were enrolled in the study (40 for each group). Before treatment, basic information (stool frequency, stool consistency, fecal incontinence, abdominal pain, pain during defecation) were recorded. During the study, daily symptoms were recorded by the standard form. The data collected during the study were analyzed by SPSS software.
Participants including major eligibility criteria:
Inclusion criteria: children with functional constipation (Rome III criteria)
Exclusion criteria: use of other medication for functional constipation except polyethylene glycol in 1 last month; The presence of organic cause; Dissatisfaction of parents or Patient
Intervention:
Use of probiotic of Bacillus Coagulans as adjuvant treatment of functional constipation by adding to polyethylene glycol
The main outcome variable:
The mean stool frequency, stool consistency, fecal incontinence, abdominal pain, pain during defecation.