The cumulative incidence of awareness during anesthesia comparing isoflorane - based versus propofol with alfentanil (TIVA) anesthesia

Objectives: The study aimed to investigate the methods for better and less awakening complication in the patients by comparing two general anesthesia (the gas isoflurane anesthesia and mixture injection of propofol and alfentanil). Study design: Double-blind for the patients and investigators, randomized , one trial study. Study setting and conduct: All patients will be under the same conditions of induction of general anesthesia and mechanical ventilation. In the two groups, two different drug will use to sustain anesthesia. The studied patients in two stages will be under the investigation. The standard questionnaire designed by Brice., 1970 will use by people who are unaware of the type of used drugs to assess the presence of awareness during anesthesia. Participants including major eligibility criteria: Volunteer surgery patients in the age group 16 to 70 years old. Major exclusive criteria: Patients which before anesthesia does not able to speak;patients who are not able to talk in the recovery room after anesthesia;severely ill;suspected under coma patients which brought to the operating room; patients with less than 4 hours staying after surgery in the hospital; mental illness and those who are taking psychiatric drugs. Sample: Two groups of 200 patients. Interventions: The first group to sustain anesthetic will inhale isoflurane gas and the second group will inject such mixture of the proposal and alfentanil. The intervening time: After induction of general anesthesia and mechanical ventilation in the operation room. Variable of main outcome: Intraoperative awakening is an independent continual variable and drugs are as the independent nominal variant.

University of Medical Sciences Shiraz(international branch).