Evaluation the efficacy of polyamine-deprived dietary regimen on Angiogenic growth factors and Tumor markers in patients with Lung cancer

Main goal: Evaluation the efficacy of polyamine-deprived dietary regimen on Angiogenic growth factors and Tumor markers in patients with Lung cancer, Inclusion Criteria: age between 30 to 70; healthy function of liver and kidney; lung cancer diagnosis Exclusion Criteria: Chemotherapy; Food supplement or other dietary regimen; diabetes patients. Patients with lung cancer betwwen 30 to 70 which referred to Shafa Hospital under supervision of Oncologist will recruit in this study.Sample size in each group will be 30. All of them befor chemotherapy devided in two groups and then under the supervision of dietition will be under specefic regimen with low level of polyamine and for inhibition of intestinal production of polyamine give Neomycin. 5 cc blood from all participant will obtain and blood keep in -30 C until analysis, for analyzing following parameters : Hepatic Growth Factor, Eidermal Growth Factor Receptor, Matrix MetalloProteinase 1, TIMP Metallopeptidase Inhibitor 1, Plasminogen Activator Inhibitor 1, urokinase (uPA)-mediated plasminogen activation, Vascular cell adhesion protein 1, Intercellular Adhesion Molecule 1, and tumor markers including Squamous Cell Carcinoma, Carcinoembryonic antigen Cyfra-21and also Interleukin -10 Interleukin 2

Ahwaz Jondishapoor University of Medical Sceinces