Evaluation of the efficacy of Calcitriol treatment on acute kidney injury improvement

Objectives: evaluating therapeutic effects of active form of vitamin D on acute kidney injury (AKI) improvement. Inclusion criteria: AKI patients aged 18 or more; voluntary participation in the study; admission in ordinary ward, CCU or ICU. exclusion criteria: using vitamin D or its derivatives or having serum Ca level more than 10.5 mg/dl at the beginning of study ; any type of malignancy leading to serum Ca more than 10.5 mg/dl. design: a single blind study (for patients only) on 122 AKI cases in two hospitals who were randomly divided in to two groups including 61 patients each by block A and B method, matched for age, sex, AKI type and severity .setting and conduct and intervention: intervention group patients received 0.25 mg/day calcitriol at the time of AKI diagnosis up to recovery or for three months if recovery did not occur. Control group received placebo as a capsule filled with starch daily since AKI diagnosis up to recovery or for three months if recovery did not happen. BUN and creatinine were checked daily during admission, then weekly for the first month since diagnosis and monthly for 3 months thereafter. after 3 months, recovery time, admission duration, dialysis sessions and maximum creatinine level during admission, frequency of developing chronic kidney disease (CKD) and mortality rate were compared between two groups as primary outcome measures. plasma calcium and phosphorus level were compared at the beginning and at the end of intervention between two groups as secondary outcome measures.

Arak University of Medical Sciences