The aim of this study is to evaluate the effect of vitamin E fortified whey drink on nutritional status, inflammatory markers and oxidative stress in hemodialysis patients.
92 hemodialysis patients will be selected for the study. Inclusion criteria: mean age of 17-65 years old; having mild, moderate or severe malnutrition based on the SGA (subjective global assessment) assessment; be dialyzed at least 2 times a week for 3 months. Exclusion criteria: hospitalization in the last month; active infection; using immunosuppressant drugs or multi-vitamins; pregnancy.
Weight and height of the patients will be recorded for BMI (body mass index) calculation. Informed consent will be signed by all of them for participating in the study. Then, all of the patients will be divided into 4 groups:
1-consumption of 230 milliliters of whey drink three times a week,
2-consumption of 230 milliliters of whey drink fortified with 400 milligrams of vitamin E three times a week,
3-consumption of 400 milligrams of vitamin E three times a week,
4- control group: no intervention,
Patients will be followed for 2 months. At the beginning and the end of the 2-month intervention period, 10 milliliters of blood will be taken from all of the patients and nutritional status of the patients will be assessed as the primary outcome. Serum levels of malondialdehyde, c-reactive protein, albumin, transferrin and lipoproteins will be measured. SGA, MIS and SF-12 questionnaires will be filled for all of the patients at the beginning and the end of the study.