Project goal: Evaluation of clinical efficacy of a topical formulation of Cinnamon essential oil in treating acne symptoms
Design of study: Non-Randomized, Non-blind, without placebo control, Single-center, Phase 2-3 trial.
a-Study group: Patients with mild to moderate acne.
Major inclusion criteria: Age of 20-58 years, Mild to Moderate Acne affection, without cystic acne, having at least 15 inflamed and 15 non-inflamed acne lesions on the face.
Major exclusion criteria:
History of acute disease of patient or any type of sensitivity or allergy to the components of medication. Using topical anti-acne medications which include vitamin A, Alpha or Beta-hydroxy acids, Retin A, Antibiotics or benzoyl peroxide during 4 weeks before the beginning of intervention. Using oral antibiotics for treating acne during 1 month before the beginning of intervention. Using systemic isotretinoin or application of laser therapy, microdermabrasion and chemical peeling during 6 month before the beginning of intervention. Pregnant or Lactating women. Women who want to be pregnant in the next 6 month after the beginning of intervention. Patients who are exposed to long-term and direct sunlight or UV lamps, without skin protection, due to their occupation. Patients who do not follow the protocol of treatment.
Sample size: 15 patients.
b-Study intervention/interventions: Application of a topical formulation including Cinnamon essential oil.
c-Intervention period: 8 weeks.
Primary outcome or outcomes of the study: Changes in sebum production, skin erythema, Transepidermal water loss, pH, the number of comedones, and skin lesions.