A Comparison between the effects of Dexmedetomidine and Morphine used by patient-controlled anesthesia pump Method on controlling the side effects of Post-operative coronary bypass surgery in intensive care unit at Bushehr heart center in 1394 to 1395

Objective of the study: To compare the effects of two analgesics, Dexmedetomidine and Morphine used by patient-controlled anesthesia pump on the side effects of post operative coronary bypass surgery in Intensive Care Unit of Bushehr heart center in 2016 to 2017. This is a randomized, single-blinded trial containing interventional and control groups. Methodology: The population is composed of 80 patients between the ages of 40 to 80 years who will be grouped into two groups of A and B. Inclusion criteria: Ejection fraction percentage less than 35 %; Patients with informed refusal after the explanation of the procedures; Patients who need reoperation in the first 24 hours after the surgery; Drug Addiction. Intervention: after randomization, Patients in group A( interventional group) will be subjected to patient-controlled Anesthesia pump containing 100 cc Normal Saline + 200 micro gram Dexmedetomidine + 4 mili gram Ondansetron with the rate of 0.7 micro gram per kilo gram per hour and group B (control) patients will be subjected to patient-controlled Anesthesia pump containing 10 miligram Morphine + 4miligram Ondansetron with the rate of 0.015 miligram per kilo gram per hour. This study will be performed from 03/04/2016 to 19/03/2017. Outcomes which will be measured and compared in this study between the groups are: severity of the pain, changes of Hemodynamic parameters, the amount of required Narcotic analgesias, the frequency of nausea and vomiting and also the level of sedation.

Vice chancellor for research, Bushehr University of Medical Sciences