This study has been done in the form of randomized clinical trial with two parallel groups , in order to investigate the Effect of dietary flaxseed on adiponectin , leptin, lipid profile and anthropometric indices in overweight or obese women. Inclusion criteria: women between 20-50 years old; body mass index over 25 kg and less than 40 kg. Exclusion criteria: taking any medication or supplements that affect fat metabolism in the body and affect weight loss during last 3 months; history of allergy to flax seed; clinical diagnosis of kidney dysfunction, liver, heart, thyroid; history of cardiovascular disease, cancer, diabetes, gastrointestinal disorders that affect absorbtion; pregnancy; lactation; not willingness to cooperate. Individuals are invited to participate in the study through public invitation (published in the newspaper or some organization under observation of Shiraz University of Medical Sciences). After that, individuals are assigned randomly into two groups of weight loss diet with 25 g / day of milled dietary flax seed or weight loss diet with 25 g / day raw rice flour for 12 weeks. Randomization is done through bock randomization method. Required energy intake per day calculated for each participant through Estimated Energy Requirement formula (EER) and we will subtract 500 kcal of the amount we calculated. Follow up will be done in 0, 4, 8, 12 weeks. In the first visit (week 0), baseline data is collected and patients will receive milled flax seed powder or raw rice flour for 4 weeks. In each follow up session, patients will receive sufficient quantities of milled flax seed powder or raw rice flour. Adherence to study protocol will be checked by asking participant to bring back the amounts of powder that they haven’t use and these amounts will be weighed and values will be recorded in each follow up. Participant in each group will be recommended to add powder into yogurt and use them half an hour before lunch. Anthropometric measurements (height, weight, waist circumference, hip circumference) will be done for each participant at baseline (0 week) and at the end of the study (12 week) .The blood sampling is done in order to measure biochemical parameters, including lipid profile (total cholesterol, LDL-c, HDL-c, triglycerides) and neuro hormonal systems (leptin and adiponectin) at the beginning and at the end of the study. For all participants 24-hour dietary recall for 3 days including a holiday and two business days will be completed through interviewing or telephone call, at the beginning and at the end of the twelfth week. Physical activity levels are calculated by using two working days and a holiday at the beginning and at the end of week 12. Clinical, laboratory and food intake indices are evaluated at the beginning and at the end of study.