This is a quasi-experimental, randomized, placebo controlled study. It aims to examine the effects of ginger supplement and high intensity interval training on serum levels of soluble intracellular adhesion molecule type 1, monocyte chemotactic protein type 1, and interlukine 10 in overweight women. Twenty-four healthy women who meet inclusion criteria (age between 20 to 30 years; body mass index between 25 to 29.9 kilogram/squared meter) will be randomly allocated into 3 groups. They involve ginger (n=8), train+ginger (n=8), and train+placebo (n=8). The groups will perform high intensity interval training for 10 weeks (40 meter maximal shuttle run, from 8 to 10 a.m.) and ginger consumption (3 gram of Vomigan Ginger tablet produced in Dineh Company, Iran, 1 gram before each meal with a glass of water) or placebo (3 gram of Gram Flour tablets produced in Dineh Company, Iran, 1 gram before each meal with a glass of water) on a daily basis. Effects of the interventions will be studied on soluble intracellular adhesion molecule type 1, monocyte chemotactic protein type 1, and interlukine 10 as primary outcome variables and on blood pressure, body fat percentage, Vo2max, cardiac structural and functional variables, and lipid profile as secondary outcome variables. Exclusion criteria include cardiovascular and respiratory problems; diabetes; high blood pressure; orthopaedic diseases; smoking; pregnancy; performance of regular exercise training during last year; and menstural disorder.