The purpose of this study is the comparison between the two drugs of Detrozitol and Sulfiniyacin. So , to help the appropriate prescribing drug to patients with overactive bladder. In this study, women with overactive bladder referring to Imam Khomeini hospital after history taking and physical examination by Using the urine three-day chart and questionnaire are checked. Women Age more than 18 years of age, incontinence urgency, urinary frequency more than 8 times at a day and more than once at night or sense of urgency to urinate in 24 hours were the inclusion criteria's. Then, the 100 patients were enrolled by using a table of random numbers and are placed in one of the groups receiving the drug of Detrozitol(n=50) and Sulfiniyacin(n=50). The drugs were excluded of Blister and were placed ina paper bags withouta name and with a code. The questioning, the patient and the analyst were blinded to it. Only someone who has been encoded was aware of the contents of the envelope. In both groups, the patients use of drug, once a day and orally for 8 weeks, and again at the end of the treatment, the questionnaire, physical examination, and the patient's chart were assesed. The primary outcomes were the effects of the two drugs on symptoms of overactive bladder (Urine frequency, Nucturia) and the secondary outcome was the drug side effects.