This study is a single blind randomized clinical trial to compare the effects on pain and morphine, fentanyl pain in patients with femoral shaft fractures were admitted to the emergency. Inclusion criteria: patients with femur fractures, one-sided, single and classification of 1 or 2 ASA; patients 18 to 55 years of both sexes; a maximum of 20 minutes after arrival to the emergency department trauma. Exclusion criteria were: decreased level of consciousness (GCS less than 14) and neural tube defects (FND); respiratory depression, hypotension (systolic blood pressure <90) and generally patients with hemodynamically unstable; multiple trauma (injury to intra-abdominal organs, bleeding Notably, head trauma); Tyad to drugs. Patients in group 1 (35 patients receiving 1.0 mg kg intravenous morphine sulfate with distilled water to a final volume reached 10 ml) and group 2 (35 patients, 5.1 mg kg group receiving fentanyl intravenous (12)) are. Two groups of patients before and after injection (0), 15 minutes and 30 minutes after treatment by visual analogue scale (Visual Analog Scale- VAS) are evaluated, as well as possible side effects and vital signs (blood pressure systolic and diastolic, heart rate and respiratory rate, body temperature) and arterial oxygen saturation, as well as in patients by Czech list has been prepared for this purpose, is recorded.