Comparison of Metoclopramide and Dexamethasone versus Metoclopramide itself in the control of vomiting due to minor head trauma in the age range of 2-8 years old

Goal: Comparison of Metoclopramide and Dexamethasone versus Metoclopramide alone in the control of vomiting due to minor head trauma in the children age range of 2-8 years old. Inclusion criteria: Patients with GCS 14-15; minor trauma associated with vomiting and normal CT. Exclusion criteria: unstable hemodynamics; neurological disorders; restless leg syndrome; the use of antiemetic medications during past 8 hours; recent receipt of injectable drugs; Nausea and vomiting caused by motion sickness; chemotherapy and radiotherapy; having contraindications for dexamethasone; simultaneous treatment with corticosteroids; diarrhea and a child who is under treatment with sedative drugs. This study will be done as a double-blind randomized controlled trial. We will recruit 60 patients, which has nausea and vomiting followed by minor head trauma, which were referred to the hospital. Twenty minutes before intervention, consciousness of patients and the severity of vomiting, will be recorded based on Visual Analog Scale. This test is a criterion for measuring the intensity of vomiting. A group of patients will receive 0.15 mg/kg Intramuscular injection of Metoclopramide and 0.15 mg/kg intramuscular Dexamethasone; and the other group will receive 0.15 mg/kg intramuscular Metoclopramide and 0.15 mg/kg intramuscular distilled water (placebo). Then, after 20, 40 and 60 minutes, and then every hour up to four hours after intervention the vital signs including (respiratory rate, heart rate,…) and their level of consciousness and also the variations and severity of vomiting will be recorded and will be checked by phone call. Finally, the differences between the two groups will be examined.

Ahvaz Jundishapur University Of Medical Sciences, Ahvaz, Iran