Clinical trial of pregnancy outcome in women with thin endometrium after intrauterine infusion of autologous platelet rich plasma (PRP) in comparison with women with thin endometrium without intervention undergoing frozen thawed cycles

Objective: This study compares pregnancy outcome in two groups of 33 infertile women between 18 to 42 years with thin endometrium after intrauterine infusion of autologous platelet rich plasma (PRP) and thin endometrium women without intervention undergoing frozen thawed cycles.Design: this is a randomized clinical trial phase 3 study which is conducted in Yazd research and clinical center for infertility.Setting and conduct: in 2nd day of cycle a basic trans vaginal sonography is performed for the women. For all the women who enter in frozen thawed cycles, estradiol tablet 2mg three times daily is initiated. In 13th day of cycle trans vaginal sonograghy is done for the patients again.Participants: those who have endometrial thickness below 7mm enter in the study. They are divided in 2 groups randomly with table of random numbers with computerized software. In control group estradiol is continued for another 3 days Intervention: in interventional group PRP is infused intrauterine with IUI (intra uterine insemination) catheter. Endometrial thickness is measured after 48 hours. If endometrial thickness doesn't reach 7mm or above, the second dose of PRP will infuse. After 48 hours the endometrial thickness is measured and for whom with endometrial thickness above 7mm vaginal suppository Progesterone400 mg twice daily is prescribed for 3 days then embryos in cleavage state are transferred.Main outcome measures: chemical pregnancy is evaluated with checking Bhcg 2 weeks after embryo transfer and clinical pregnancy is proved with trans vaginal sonography and observation of fetal heart 2 to 3 weeks after positive pregnancy test

Yazd Shahid Sadoughi University of Medical Sciences,Vice chancellor for research