This study is a double blind clinical trial to evaluate the effect of supplementation hesperidin serum glucose, insulin, resistance to insulin, hemoglobin A1 C, lipid profile, hs-CRP and IL6 on 48 type II diabetic for 2 months. The patients will be recruited from Institute of Endocrinology and Metabolism, Iran University of Medical Sciences,that the disease has been diagnosed by a doctor. the subjects will be 20-65 y of age. Inclusion criteria are absence of cardiovascular disease, liver disease, kidney disease, inflammation and disease chronic digestive system and will have a BMI of less than 35. Exclusion criteria are، taking insulin, following weigh-reducing diets.The study will be explained to each subject.The subjects were randomly divided into two group recipient supplement hesperidin and contro.The study will be explained to each subject, who signs an informed consent Prior to the study, the subjects will be required to complete 3-days 24-hour dietary recall. Blood samples will be obtained after an overnight fast before and after the study. All anthropometric and physical activity variables will be measured both before and after the trial. Compliance will be assessed from 3-days 24-recalls which obtain at first, in the middle and at the end of the study. Diets and medications dosage will be held constant throughout the study and each subject’s exercise level will be kept constant and monitored by physical activity questionnaires (IPAQ).