Objectives: The Main objective of this study is to compare the effect of oxytocin versus oxytocin– propranolol on labor progression
Study design: This study will be done randomized single – blind clinical in Sayyad Shirazi Hospital, Gorgan
Inclusion/exclusion criteria: Inclusion criteria includes 37 to 41 weeks gestational age according to certain LMP and confirmed ultrasound in the first quarter, also nuliparity, singleton, cephalic presentation, intact membranes and bishop score equal to or less than 5 are among the inclusion criteria.
Exclusion criteria includes CPD, any history of previous surgery on the uterus, fetal distress, the risk of macrosomia or polyhydramnius, SBP≤100, PR≤60, PR≥120 min, any history of cardiopulmonary disease, metabolic disease of mother or taking medicine for any illness by mother.
Interventions: In oxytocin group, use of oxytocin will start at 2mIU/min and every 15 minutes the same amount will added to create a good contraction (3 contractions in 10 minutes) this continues maximally up to 8 hours. In entering the active phase of labor induction continues to delivery, in case of no entry to the active phase (3- 4 cm Dilation) stop induction after 8 hours and continues it the next day. In the absence of response to induction the second day will be cesarean section. In the propranolol group before induction, 2 mg propranolol will infuse intravenously and slowly and then induction starts with oxytocin the same as mentioned above. If the condition continues for the second day, use injection of 2 mg propranolol through vein and continue all induction processes. Control patient s blood pressure and fetal heart rate in every 15 minutes and follow the patient status and note down the information until delivery.