We are comparing the effect of Dexmedetomidine and Dexamethasone and Metoclopramide, for prevention of nausea and vomiting in Tympanomastoidectomy surgery.
We are going to enroll all patients who have elective Tympanomastoidectomy surgery and are sedated by general anesthesia that referred to Amirkabir hospital and have inclusion criteria. In this study we don't use placebo and it's double blind and randomized cases.
We will measure and record the Heart rate and mean arterial Blood pressure and Blood Oxygen saturation, before the surgery for all patients and take ECG for all of them.
In all groups, 10 minutes after tracheal intubation, interventional drugs will be administered [Dexmedetomidine (dexmed) 1 mg/ kg / IV in group A, Dexamethasone (dexa) 8 mg / IV in group B and Metoclopramide (meto) 10 mg / IV in group C that their volume increased to 4 ml by Saline.]
The research assistant who knows nothing about our classification, will prepare the drugs and code.(double-blind)
At different times of operation [before administering interventional drugs (T0), at 5 minutes after administering (T1), at 30 minutes after administering (T2), at 5 minutes after extubation (T3), at the time of entrance to recovery room(T4)], we will measure blood pressure and Heart rate.
At the first 24 hours after operation (every 6 hours), We will evaluate the patient's nausea and vomiting. The score of Nausea and Vomiting will be recorded.
If score of nausea in one patient is more than 60 (according to VAS score) or if he/she asks antiemetic drugs, We will provide him or her with 4 ml Ondansetron and that time will be recorded.