Compare of The efficacy of Pregabaline and Carbamazepine on patients with Trigeminal Neuralgia

Evaluation of Pregabaline efficacy in patients with Trigeminal Neuralgia

In the study twenty patients suffering from idiopathic trigeminal neuralgia are selected according to international headache society criteria. They are assigned randomly in two similar groups with ten patients in each group. Patients in group one take Pregabaline seventy five milligrams twice daily for thirty days and patients in Group two takes Carbamazepine two hundred milligrams twice daily for thirty days. After five days free interval without drug patients in group one take Carbamazepine and patients in group two take Pregabaline for the same dose and period. Selection the group of first patient is by lottery and next cases alternately are assigned in two groups.

Study will accomplish in neurology clinic of Mostafa Khomeini hospital. Study design is explained to all patients and all of them have written consent according to instructions of ethical committee of Shahed University. All drugs are put in uniform packages and special code is assigned to each one. Patients, main researchers and assessors are not aware of drugs kind and patient's group. All data are recorded and groups compared each other with statistical analysis.

Inclusion criteria: Age between eighteen to seventy-five years old. Suffering from idiopathic Trigeminal neuralgia according to international headache society criteria. Exclusion criteria: Patients with other kinds of head and facial pain. History of psychiatric problems, liver failure, renal failure, heart failure, thrombocytopenia, leukopenia, anemia and malignancy. Pregnancy and breast feeding.

Group one of patients takes Pregabaline seventy- five milligrams twice daily for thirty days and Group two takes Carbamazepine two hundred milligrams twice daily for thirty days. After five days interval free of drugs group One of patients take Carbamazepine and group two takes Pregabaline for the same dose and period. Selection the group of first patient is by lottery and next cases alternately are assigned in two groups.

Pain intensity is evaluated by Visual analogue scale and 5-points verbal rating scale before starting and in the twenty-eight to thirtieth day of each cycle. Frequency of repeat of pain attacks before starting and in the day twenty- eight to thirtieth of each cycle.

All selected samples are given one number and then are assigned in two groups alternatively by use of random number chart. group one take Pregabaline for thirty days and group two take Carbamazepine for the same period. After five days interval without any drug patients in group one take Carbamazepine and patients in group two take Pregabaline for the same period. Selection of group for the first patient is by lottery.

All drugs are inserted in uniform packages and mark by specific code . Drugs are given to patients in the way that,participitants ,main researchers and assessors of signs and symptoms from all groups such as physicians or students are not aware of patient 's group and the kind of drugs. Study design and steps are explained for all patients but they are not aware of their group and drug kind which started for them.