The effect of oral moisturizing gel containing aloe vera and peppermint oil on Xerostomia and Mucosal-Plaque in intubate patients in ICU

Objectives: Identify the effect of oral moisturizing gel containing aloe vera and peppermint oil on Xerostomia and Mucosal-Plaque in intensive care unit patients Design: a triple blind randomized clinical trial. Setting and conduct: The eligible patients who will admitted to intensive care unit of Amin Hospital during the study period will be enrolled into the trial. Inclusion criteria: age range of 18–65 years; no chronic disease; being intubated during the study period ; Less than 12 hours Intensive care unit length of stay . Exclusion criteria: being discharged from ICU; patient’s death; Intervention group: Using topical oral moisturizing gel containing aloe vera and peppermint oil twice a daily( Every 12 hours) apply 10 gr for 7 days. Control group: Using topical placebo twice a daily( Every 12 hours) apply 10 gr for 7 days Primary outcome: Assessing xerostomia before and after treatment through Challacombe Scale and Assessing mucosal-plaque formation before and after treatment through mucosal-plaque Score. Secondary outcome: Assessing local reactions such as hives, or redness after treatment through physical examination. Randomization: The patients will be randomly assigned to intervention and control groups using block randomization. Blinding: Patients will be unaware of the type of intervention. The physician who will examine the patients will not be aware of the intervention. The analyzer will be unaware of the type of interventions. Therefore, the trial will be run as triple blind.

Isfahan University of Medical Science