Comparison of the effects of remifentanil and dexmedetomidine on recovery profile of patients after hysterectomy operation under anesthesia with venous propofol

• Objectives: Comparison of the effects of remifentanil and dexmedetomidine on recovery profile of patients after hysterectomy operation under anesthesia with venous propofol • Design: patients referring to the Firozgar hospital who are candidate for hysterectomy provided informed consent will be randomly assigned into two groups of dexmedetomidine and remifentanil. Study is phase 1/2, double-blinded and single center. • Setting and conduct: in this double-blinded randomized clinical trial, patients candidate for hysterectomy will be recruited according to the inclusion and exclusion criteria. All patients will sign informed consent forms. Anesthesia induction will be performed and the patients will receive 1 µg/kg of dexmedetomidine in 15 minutes and then 2 µg/kg/hour in the dexmedetomidine group and remifentanil 1 µg/kg/minute in the remifentanil group as infusion until the end of operation. • Participants including major eligibility criteria: patients candidate for elective hysterectomy operation in Firozgar hospital with ASA I-II grade provided informed consent are included. Patients above 70 years of age, emergency operation, patients with cardiopulmonary, renal, hepatic, diabetes, hypertension, obesity, difficult airway, lactating women, sleep apnea and psychological diseases will be excluded. • Intervention: drugs remifentanil and dexmedetomidine • Main outcome measures: anesthesia and operation duration, ETCO2, extubation time, recovery time, bradycardia, hypotension and Aledret scale

Vice-chancellor for Research of Iran University of Medical Sciences