study aim: to determine the effect of fenugreek seeds on serum irisin level, glucose metabolism and lipid profile in diabetes type 2
study design: Randomized, controlled, no blinding, no placebo, single-center, parallel study
Methods:
A) study population:
Inclusion criteria: voluntary participation; At least 1 year and a maximum of 10 years diabetes history and observing at least 6 months diabetic diet; taking oral drugs lowering blood glucose to control diabetes; 18 to 65 years old; Lack of pregnancy and lactation; Not having certain diseases (liver, kidney, heart, thyroid, rheumatoid, respiratory, metabolic, gastrointestinal, malignancy, allergic diseases); no need for insulin; not using dietary, vitamin and mineral supplements, at least three months before the study; not hormone therapy; no smoking; no using other medicinal plants routinely, at least 3 months prior to the study
exclusion criteria:
unwillingness to continue; developing specific diseases (liver, kidney, heart, thyroid, rheumatoid, respiratory, metabolic, gastrointestinal, malignancy, allergic diseases) during the study; starting pregnancy and lactation; starting insulin therapy; starting using dietary, vitamin and mineral supplements; change in the dose of oral blood glucose lowering drugs; Change in the physical activity during the study; start taking other medicinal plants routinely
B) study intervention:
15 grams of powdered fenugreek seeds in doses of 5 grams three times a day between meals, dissolved in water
C) duration of intervention:
8 weeks
D)study outcomes:
FBS، 2hPPG ،HbA1c ، fastin insulin، HOMA-IR ، HOMA-B و QUICKI
irisin
T-chol, LDL, HDL, TG, VLDL