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Study aim
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Investigating effect of capsules containing extract of Vitex agnus castus and Nigella Sativa powder and extract in comparison with citalopram
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Design
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In this research, 46 eligible menopausal patients referring to medical centers of golestan medical university were chosen purposefully and were randomly divided into two groups of control and intervention. Group allocation was concealed by assigning a unique code to each participants.
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Settings and conduct
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In this intervention study ,which is a randomized double blinded clinical trial,46 postmenopausal women who visit the Mohab YAS Hospital are examined.At the first meeting after taking the history and complete examination ,including a breast examination and,if necessary, ultrasonography, mammography and vaginal examination , and in absence of pap smear in the last six month ,smear and obtaining written consent , and in the case of normal clinical trial,the relevant questionnaires will be completed for them.The research methodology will be based on the goal.Randomly one of the two groups receiving the 20mg Citalopram tablet and the capsule containing Nigella Sativa powder and Vitex agnus castus extract ,1mg daily after breakfast,and other group receiving 20mg of Citalopram and placebo ,for eight weeks each day and for two month ,the drugs are prescribed.
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Participants/Inclusion and exclusion criteria
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Inclusion criteria: Having hot flash symptoms, satisfaction to participate in the study, passing at least one year from menstruation after the onset of menopause
Exclusion criteria: sensitivity to the studied plants ,the emergence of any mental illness,increased symptoms of hot flashes
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Intervention groups
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1- Control group: receiving 20 mg citalopram together with placebo for eight weeks.
2- Intervention group: receiving 20 mg citalopram together with capsules containing 1g Nigella Sativa powder and Vitex agnus castus extract for eight weeks
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Main outcome variables
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examining rate of flushing and sweating in menopausal women