The main purpose of this study is to determine the effects of Curcumin on Lipid profile of serum and systemic inflammation in Hemodialysis patients. This study is double blinded .blinding is performed on giving supplementation and doing laboratory tests and operating data .64 Hemodialysis patients referred to the Montaserieh hospital have been enrolled. At the beginning of the study 5 ml of venous blood (for profiling of blood lipids and inflammatory markers at the beginning of the study) is taken from all patients before connecting to Hemodialysis devices and patients are divided into two groups of intervention and control by permutation block randomization. The intervention group will receive Curcumin supplementation for 8 weeks, 80 mg, 1 time per day and the control group will receive placebo (that contained starch at a rate of 0 /5 mg) once a day. All patients are asked not to change their diets and physical activities during the study and inform every kind of change in their consuming drugs to researchers. At the end of the study before connecting to Hemodialysis device, 5 ml blood is taken. Inclusion criteria: having a history of at least 6 months of Dialysis, Between the ages of 25 and 75 years old, non-catching infectious diseases particularly Hepatitis, non-consuming steroidal anti-inflammatory drugs, Nicotinic Acid, estrogen, progesterone and Curcumin supplementation at least 1 month before the beginning of the study. Exclusion criteria: high blood potassium during the study, unwillingness to continue to participate, increasing dose of anti-fat drugs, changes in patient's lifestyle or diet during the study, using herbal fat lowering medications during the study. The primary variables in this study are measuring : Triglycerides, Cholesterol, LDL, HDL and hs-crp and secondary variables are measuring: Urea, Creatinine, Albumin, Dialysis adequacy and BMI are.