Comparative study of the effect of propofol infusion before injection of induction dose on injection induced pain and changes in serum complement in patients candidate for general anesthesia

The purpose of this study is to evaluate the effect of propofol infusion before administration of propofol induction dose on injection pain and changes in serum complement.

In this study, 60 surgical patients undergoing general anesthesia are selected and randomly divided into three groups. Two intervention groups and one control group.

The purpose of this study is to evaluate the effect of propofol infusion before administration of the induction dose of propofol on injection pain and changes in serum complement.The design of the study is single blinded and the patient is unaware of how the intervention is conducted by the researcher. Sampling is carried out at Firoozgar Educational Center. Sample size is about 60 people.Group A is being studied as a control group and injection of induction dose is carried out without propofol infusion.In the other two groups, the intervention is administered with propofol infusion with two different doses before injection of the induction dose. Two minutes before induction of anesthesia with propofol, in group B, 50 micrograms per kg of weight per minute, and in group C, 100 micrograms per kg of body weight per minute, propofol is infused for one minute. In all three groups, a blood sample is taken at the time of IV catheterization and one specimen, one minute after injection of propofol induction dose from the same hand and above the injection site to measure the serum level of complement C3 factor. Also, when injected, the degree of pain induced by injection is evaluated using VAS.

All patients with ASA I & II physical conditions aged between 18 and 60 years old who are candidates for surgery under general anesthesia are eligible for enter the research unless they have the following conditions: Acute and chronic uncontrolled illness,Drug addiction, history of taking anti-inflammatory drugs and corticosteroids, autoimmune diseases, history of drug and food allergy (especially egg products)

In group A, the control group, is not given an intervention, and anesthetic dose of propofol (2 mg / kg) is injected one minute after administration of fentanyl (3mic / kg) and midazolam (0.15 mg / kg). In group B, propofol 50micg / kg / min is infused for one minute, then fentanyl and midazolam, and one minute later, the induction dose of propofol is injected. In group C, initially, infusion of propofol at a dose of 100mic / kg / min for one minute, then fentanyl and midazolam, and one minute later, the induction dose of propofol is injected.

Pain When Injecting Bolus Propofol Changes in serum level of complement factor C3

The cost of conducting tests is initially paid by program administrators

In this research, simple randomization method is used using sealed envelope. The patient chooses one of the three envelopes, in which the letters A, B, C are written, and is placed in one of the three groups.

During the study, the patient is simply blind because of the lack of knowledge about how the anesthetic induction was performed.The laboratory, which is responsible for assessing the serum level of complementary C3 factor, is blind. The researcher is involved in the induction of anesthesia and intervention, and is not blind to the type of intervention and non-intervention.

All information used for this research can be shared after unidentifying the identity of patients. Also, statistical information, information analysis, study method, findings and conclusions can be shared.

Starting access after accepting by a valid scientific journal and publishing it

For academic researchers and in the field of science

All researchers can use all published material and if all or part of this research is published by other people, the name and source of this research and its researchers should be mentioned.

Dr. Behrooz Zaman Email: zaman.b@iums.ac.ir

The applicant can request the type of files by email.