Effect of Six Weeks Combined Supplementation of Methylsulfonylmethane and Glucosamine on the Glutathione Peroxidase and Catalase following a Plyometric Exercise Session in Amutor Male Athletes
Intensive physical activity results in release of free radicals and oxidative damages in biomacromolecules. Consumption of sulfuric supplements may effect on the levels of oxidative stress following intensive exercises, spicially in combined concentric and eccentric contractions. Therefore, the effect of six weeks combined supplementation of methylsulfonylmethane and glucosamine on the glutathione peroxidase and catalase following a plyometric exercise session in amutor male athletes will be studied in the present study.
The study will be a double-blinded quasi-experimental reseach with a pre- and post-test design in which 22 amutor male athletes will be randomly assigned into two groups of supplement (n = 11) and placebo (n = 11), and participated in two bouts of plyometric exercise before and after the supplementation period. The supplementation period will include daily consumption of 3 grams combined methylsulfonylmethane and glucosamine for six weeks. The serum levels of superoxide dismutase and malondialdehyde enzymes will be determined based on the four-times blood sampling (before and after the two plyometric exercise sessions), and the collected data will be analyzed using analysis of covariance (ANCOVA) at the 95 percent confidence level.
We expect the combined supplementation of methylsulfonylmethane and glucosamine increase anti-oxidant capacity in athletes through increased levels of glutathione peroxidase and catalase enzymes.
General information
Acronym
IRCT registration information
IRCT registration number:IRCT2017032632873N2
Registration date:2017-06-28, 1396/04/07
Registration timing:retrospective
Last update:
Update count:0
Registration date
2017-06-28, 1396/04/07
Registrant information
Name
Farzad Zehsaz
Name of organization / entity
Islamic azad University, Tabriz Branch
Country
Iran (Islamic Republic of)
Phone
+98 41 3196 6245
Email address
f-zehsaz@iaut.ac.ir
Recruitment status
Recruitment complete
Funding source
Investigator
Expected recruitment start date
2017-05-15, 1396/02/25
Expected recruitment end date
2017-05-22, 1396/03/01
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Effect of Six Weeks Combined Supplementation of Methylsulfonylmethane and Glucosamine on the Glutathione Peroxidase and Catalase following a Plyometric Exercise Session in Amutor Male Athletes
Public title
Effect of Supplementation on athletes oxidative stress
Purpose
Prevention
Inclusion/Exclusion criteria
Inclusion criteria: male kick boxor; amateur; from Tabriz City; healthy
Exclusion criteria: having any illness; using drug
Age
From 20 years old to 30 years old
Gender
Male
Phase
N/A
Groups that have been masked
No information
Sample size
Target sample size:
22
Randomization (investigator's opinion)
Randomized
Randomization description
Blinding (investigator's opinion)
Double blinded
Blinding description
Placebo
Used
Assignment
Parallel
Other design features
Secondary Ids
empty
Ethics committees
1
Ethics committee
Name of ethics committee
Islamic Azad University, Tabriz Branch
Street address
Medical Faculty, Tabriz Islamic Azad University Campus, Pasdaran Highway
City
Tabriz
Postal code
Approval date
2016-10-24, 1395/08/03
Ethics committee reference number
IR.IAU.TABRIZ.REC.1395.38
Health conditions studied
1
Description of health condition studied
Oxidative Stress
ICD-10 code
F43.1
ICD-10 code description
Post-traumatic stress disorder
Primary outcomes
1
Description
Glutathione Peroxidase
Timepoint
Before intervention and after 6 weeks of the begining of intervention
Method of measurement
(U/gHb) by blood sampling
2
Description
Catalase
Timepoint
Before intervention and after 6 weeks of the begining of intervention
Method of measurement
(U/gHb) by blood sampling
Secondary outcomes
empty
Intervention groups
1
Description
Intaking of combined supplementation of Methylsulfonylmethane and Glucosamine by experimental group for 6 weeks and 3 gr daily
Category
Prevention
2
Description
Intaking of 3 gr Starch by placebo group for 6 weeks
Category
Placebo
Recruitment centers
1
Recruitment center
Name of recruitment center
Whole Kickboxing clubs of Tabriz
Full name of responsible person
Mehrabani Ali
Street address
Physical Education Department, Tabriz Islamic Azad University Campus, Pasdaran Highway
City
Tabriz
Sponsors / Funding sources
1
Sponsor
Name of organization / entity
Islamic Azad University Tabriz Branch
Full name of responsible person
Dr. Naser Modir Shahla
Street address
Research Deputy of Islamic Azad University of Tabriz, Tabriz Islamic Azad Campus, Pasdaran Highway
City
Tabriz
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Islamic Azad University Tabriz Branch
Proportion provided by this source
100
Public or private sector
empty
Domestic or foreign origin
empty
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
empty
Person responsible for general inquiries
Contact
Name of organization / entity
Islamic azad University, Tabriz Branch
Full name of responsible person
Farzad Zehsaz
Position
Academic Staff Member
Other areas of specialty/work
Street address
Physical Education Department, Tabriz Islamic Azad University Campus, Pasdaran Highway
City
Tabriz
Postal code
Phone
+98 41 3196 6245
Fax
+98 41 3196 6245
Email
f-zehsaz@iaut.ac.ir
Web page address
Person responsible for scientific inquiries
Contact
Name of organization / entity
Islamic azad University, Tabriz Branch
Full name of responsible person
Farzad Zehsaz
Position
Ph.D. in Exercise Physiology
Other areas of specialty/work
Street address
Physical Education Department, Tabriz Islamic Azad University Campus, Pasdaran Highway
City
Tabriz
Postal code
Phone
+98 41 3196 6245
Fax
+98 41 3196 6245
Email
f-zehsaz@iaut.ac.ir
Web page address
Person responsible for updating data
Contact
Name of organization / entity
Islamic Azad University
Full name of responsible person
Farzad Zehsaz
Position
Ph.D. in Exercise Physiology
Other areas of specialty/work
Street address
Physical Education Department, Tabriz Islamic Azad University Campus, Pasdaran Highway
City
Tabriz
Postal code
Phone
+98 41 3196 6245
Fax
+98 41 3196 6245
Email
f-zehsaz@iaut.ac.ir
Web page address
Sharing plan
Deidentified Individual Participant Data Set (IPD)