Inclusion criteria: UPDRS= mild and moderate stage,
No family background of parkinson disease, BMI between 18-25, No peptic ulcer history, surgery or hemorrhage of gastrointestinal system, No NSAIDs or continuous systemic corticosteroid use for two previous months of research, No alcohol consumption, Age between 55 and 85, No record of other specific central nervous system disease like Alzheimer’s disease, multifactorial dementia, medulla oblongata dementia, Huntington’s disease, hydrocephalus, brain tumors, severe supra nuclear palsy, epilepsy, flocculation among brain tissue layers, or multiple sclerosis, Not taking drugs that might affect cognitive behaviour or perception like estrogen, deprenyl, vitamine E, neuroleptic compounds and anticholinergics, No consuming complements containing vitamine B12 or folic acid, No severe heart or vascular disease, No kidney or liver disorder
Exclusion criteria: Acute viral, bacterial or severe infectious disease during research