The aim of this single-blind clinical trial study was to evaluate of axillary perineural injection of dexmedetomidine on hemodynamic factors during surgery and post-operative pain in patients undergoing upper orthopedic surgery in Shahid Beheshti Hospital, Kashan. Inclusion criteria including patients aged between 18 and 65 years, ASA class I, II, Fracture of the forearm and hands bones, BMI ≤ 35 and Patient consent form for study participation and exclusion criteria including Pregnancy, addiction, history of use of agonist or 2α adrenergic antagonist's drugs, coagulation disorders, hypersensitivity to intraoperative drugs and prolonged surgery for more than 120 minutes. Samples were randomly divided into two groups of 30 individuals in intervention and control groups. Patients will receive premedication of 0.05mg/kg Midazolam and 3μ/kg Fentanyl. The intervention group 100 μg Dexmedmotidine infusion in the auxiliary and pre- neural region. No injections was used in the control group. Induction was carried out by using 5mg/kg Sodium thiopental and 0.5 mg/kg atracurium. BIS is maintained in the range of 40 to 60 during the operation. At the end of surgery, all patients were reversed by 30μ/kg Atropine and 50μ/kg Neostigmine injections. Vital sign changes were recorded prior to the induction and every 15 minutes during the surgery. Postoperative pain was evaluated in recovery and 3, 6, 12 and 24 hours after surgery using VAS scale. Drug intake was recorded in the recovery and 24 hours after surgery.