Objectives: effect of telephone counseling and follow-up on fatigue, pain, and quality of life in multiple sclerosis patients. Design: randomized clinical trial. Setting and conduct: Multiple Sclerosis patients who will refer to Multiple Sclerosis Clinic of Sina Farshchian educational hospital in Hamadan Iran. Inclusion criteria: diagnosis of the disease by a neurologist; age over 18 years; history of the disease for at least 6 months; lack of relapse; lack of any other acute or chronic disease; mobile access and lack of any cognitive or psychological disorder. Exclusion criteria: no ability to continue participation to any reason (such as accident, death or moving to another city); hospitalization during the study period; no willingness to continue participation in study; no possibility to cell phone connection. Interventions: At the first, the patients in the intervention and control groups will receive an educational package. Then, telephone counseling and follow-up intervention will be conducted, lasting 5-15 minutes, according to the established agreement, between eight morning and eight evening. The telephone counselling and follow-up plan is as follows: at the first week, researcher will conduct two counselling calls about the treatment plan (providing advice on how properly take drugs according to the physician’s orders). At second week, researcher will conduct two phone calls focusing on a diet plan which involves consuming proper foodstuffs, the importance of maintaining a healthy diet, appropriate nutrition for controlling bladder problems and constipation, appropriate nutrition for controlling chewing and swallowing problems and role of vitamins in recovery of multiple sclerosis disease. In third week, researcher will conduct two phone calls addressing the importance of exercise, recommended activities, and advice on how to do them. At forth week, researcher will conduct two phone calls focusing the role of stress in relapsing the symptoms and decreasing stress. During the second 4-week period, all the content of delivered educational package will be reviewed by making one follow-up call every week. Patients could freely call the researcher for counseling if they have any questions. The control group will receive only routine care. Measurement of major consequences: Fatigue, pain, and quality of life will be assessed by Croup Fatigue Questionnaire before and after the intervention; the pain will be assessed using the visual analogue scale before and after the intervention, and MSQol-54 by questionnaire before and after the intervention. Main outcome measures (variables) are fatigue, pain and quality of life.