Inclusion criteria:
Inclusion criteria:Age over 18 years ;
Beginning hemodialysis for at least 3 months and three times per week ;
Ability to understand and sign consent form ;
Use of biocompatible dialysis membrane.
Properly functioning arteriovenous fistula or catheter function;
Dialysis adequacy above 1.2.
Exclusion criteria:
Exclusion criteria : Other causes of itching, except kidney failure ;
Pregnancy ;
The presence of any chronic, active, uncontrolled or severe chronic inflammatory disease (autoimmune diseases, connective tissue disease, malignancy, HIV, liver disease and pulmonary disease) ;
presence of chronic infection or acute infection in the last month ;
Hemoglobin less than 10 g / dL ;
Co-presence in another trial ;
Medical history (such as heart attack ) or surgical in the last 3 months ;
Symptoms of malabsorption ;
Bleeding disorders ( Includes coagulopathies) or high risk of bleeding ;
Change in diet in the last 1 month;
Consumption of Omega-3 or any supplement containing omega-3 in the last 3 months. ;
Intolerance or susceptibility to drug ;
Receiving drugs that have an effect on inflammatory factors (corticosteroids or other immunosuppressive drugs, non-steroidal anti-inflammatory drugs, contraceptives, pentoxifylline) in the last 6 weeks;
Concomitant use of methyl dopa, cimetidine and serotonergic drugs such as triptans, tramadol, tryptophan and linzolide ;
Use of warfarin ;
Abuse of alcohol and other substances that cause dependence.