The present study aimed to determine the effect of omega-3 fatty acids supplementation on serum nitric oxide levels in men with coronary artery disease. Design and Implementation:In this Clinical Trial Double Blind study,42 patients are selected from Tehran Heart center. Consent form, general questionnaire, 24-hour recall of food and international physical activity questionnaire were completed.Patient's blood pressure, anthropometric measurements, height, weight and fat mass of patients are measured. Then, in order to perform the test,10cc blood sample is taken.At the end, we give patients with omega-3 supplementation at a dose of 4 g / day or placebo (oral paraffin) at a dose of 4 g / day for two months.
After 2 months,patient s physical activity, questionnaire were asked and weight,and blood pressure of the patient were measured.
inclusion criteria for this study include heart disease, any other diseases, and do not use vitamin supplements or diets at least 4-6 weeks before the intervention. Exclusion criteria are an allergic reaction to Omega-3.
In this randomized double blind study, 42 cardiac patients were selected based on inclusion and exclusion criteria. Patients were randomly assigned into two groups, including group 1- receiving omega-3 supplements and group 2-receiving placebo. The omega 3 treated group received 4 capsules of 1 g (4 g) of omega-3 daily and placebo group received 4 capsules of 1 g of oral paraffin for 3 months. Two capsules are taken along with lunch and two capsules are taken with dinner.
Primary outcome variable: Determination of mean serum NO level before and after intervention in the omega-3 fatty acid supplement group compared to placebo group