The aim of this double-blind clinical trial study was to evaluate the effect of intravenous infusion of Dexmedetomidin to control bleeding and postoperative pain in functional endoscopic sinus surgery in Matini, Kashan Hospital.
Inclusion criteria included patients aged between 15 and 75 years of age, ASA class I, II, and HB>10grdlin patient whit Pansinusitis. Exclusion criteria included history of sensitivity to Dexmedetomidin, coagulation disorders, past surgical history at the same of location, uncontrolled high blood pressure.
Samples were randomly divided into 3 groups of 32 individuals in intervention and control groups. Group A infusion Dexmedetomidin 0.2 μ/ Kg/h and Group B infusion Dexmedetomidin 0.5 μ /Kg/h, Group C infusion Normal saline with the volume equal to a dose of Dexmedetomidine. Induction was carried out by using 0.03 mg Midazolam, 2 μ/ kg Fentanyl, 2mg/kg Propofol, 0.5 mg/kg Atracurium. For maintenance purposes, 50% N20-O2 was combined with 100µ/kg/min Propofol. The bleeding rate was also examined and recorded based on the weight of gases and volume of the suction tank.In wake-up time from reverse injection until eyes opening, Patents were recovered from anesthesia whit using 0.06 mg/kg Neostigmine and 0.03 mg/kg Atropin .Main outcome measures: Bleeding volume, Systolic blood pressure, Diastolic blood pressure, O2 saturation, Heart rate, postoperative pain in recovery andin2, 6, 12, 24 hour after surgery in the ward.