The effects of oxytocin and human chorionic gonadotropin in clomiphene citrate resistant polycystic ovary syndrome patients

In this study, we decided to determine the effect of oxytocin and Human Chorionic Gonadotropin(HCG) on ovulation and pregnancy.

The randomized double blinded clinical trial in three groups of 42 cases with a parallel group was done.

Double blind clinical trial was performed on patients referred to infertility center of Shahid Akbar Abadi Hospital in Tehran. patients and doctors were blinded.

Infertile women with chronic ovulation disorder and polycystic ovarian syndrome (based on Rotterdam criteria 2003), who was treated with clomiphene citrate (150 mg) and did not pregnant, age of 19 to 45 years old, Body Mass Index of 27 to 32, at least one of the ovarian tubes with hysterosalpingography is open and no other pelvic pathology, were included in the study.. Any allergy to oxytocin and cardiovascular disease and other causes of infertility were excluded.

Clomiphene citrate resistant polycystic ovary syndrome patients were studied.The volunteers with the above conditions were randomly assigned to three separate groups. In the first group, Letrozole and human chorionic gonadotropin, in the second group, Letrozole and oxytocin and in the third group, Letrozole and HCG and oxytocin were given. Letrozole (5 mg) was given since second to the fifth day of the menstrual cycle for 5 days, to grow follicles. Then, trans vaginal ultrasonography was performed on thirteenth day of menstrual cycle to measure the dominant follicle size, follicular count and endometrial thickness. In women with a follicle of 18 to 22 mm, to stimulate ovulation, 10-unit of oxytocin and or 5,000-unit HCG were injected.

Pregnancy, Abortion, Multiple pregnancy, Dominant Follicle Size, Follicle Count, Endometrial Thickness were analysed.

In this study, after determining the sample size, Patients were randomly assigned to one of three groups using stratified randomization. Allocation Concealment was performed by sealed envelopes.

In this study, a plan was first described for the patient.The patient, the researcher and the physician did not know the group. For each treatment, the code was assigned and placed in an envelop and then put in a box, randomly.The agent who conducted the randomization process, did not engage with other steps.