The aim of this study is to determine the effect of acupressure on anxiety, self-efficacy and pregnancy in infertile women undergoing intracytoplasmic sperm insemination (ICSI) and explain their understanding and experience from this treatment. This mix method study consisted of two stages that the first part is a clinical trial. The sample size is 144 infertile women. Inclusion criteria include female infertility, primary infertility, undergoing treatment ICSI, no history of mental illness and, age between 20 to 45 years. Exclusion criteria are: stressful events during study for participants, no participation in more than 2 of intervention sessions. Then, the Beck Anxiety Inventory (Beck) is completed by them. People with severe anxiety are excluded. The questionnaires consisted of infertility self-efficacy and social support perceived questions are completed by people who entered study. The subjects are randomly divided into three groups: sham and real acupressure and control groups. Patients receive acupressure treatment three times a week for 4 weeks with ICSI. The control group will receive only ICSI treatments. Acupressure is performed until a day before the embryo transfer. Again after intervention, questionnaires are completed in three groups. An employee outside the research team will complete the questionnaires with aim of blinding or masking the study group assignment. Data analysis is done by consulting statistics. Finally, β HCG hormone assay is performed to determine pregnancy in three groups, 15 days after embryo transfer. In this study, major variables are including anxiety, self-efficacy and pregnancy rate.