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Study aim
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Determination and comparison of synbiotic supplementation effect on metabolic status, serum apelin levels and anthropometric profiles in patients with polycystic ovary syndrome
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Design
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Randomized, double-blind, placebo-controlled
Population studied: Individuals with polycystic ovarian syndrome were randomly divided into 2 groups, group1 receiving synbiotic (1 capsule 500 mg),group 2 placebo group (1 capsule 500 mg placebo),Supplements will be provided for 8 weeks.
Sample size: 68 people (2 groups of 34).
Study Intervention: Synbiotic Supplement
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Settings and conduct
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The aim of this study was to evaluate the effect of synbiotic supplementation on metabolic status in patients with PCOS referring to women's specialized clinic in Tabriz.
For each person, the general characteristics questionnaire, anthropometric evaluations,, Food registration and the International Assessment of Physical Activity (IPAQ) will be completed. To measure all biochemical parameters, 10 cc of venous blood is collected fast (at the beginning and end of the study) and their serum will be separated and kept until (70 °) until the tests are performed.
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Participants/Inclusion and exclusion criteria
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Entry criteria: Women aged 20-45 years and BMI Between 40-25, , PCOS diagnosis based on Rotterdam standard 2003
Exit criteria: history of thyroid disorders, ..., pregnancy and lactation, consumers of anti-obesity drugs ..., sensitivity to synbiotic and probiotic capsules,intake of probiotic , perebiotic, synbiotic in the last three months And during the study, regular consumption of probiotic products
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Intervention groups
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group1 receiving synbiotic (1 capsule 500 mg)
group 2 placebo group (1 capsule 500 mg placebo)
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Main outcome variables
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The effect of synbiotic supplementation on metabolic status, serum apelin levels and anthropometric profiles