Comparison the effect of Chamomile vaginal gel with Conjugated Estrogen in the treatment of vaginal atrophy in postmenopausal women

The aim of this study is to compare the effect of chamomile vaginal gel with Conjugated Estrogen on the treatment of vaginal atrophy in postmenopausal women.

In this study 96 postmenopausal women with vaginal atrophy and have include criteria into the study, are randomly divided into two intervention groups and one control group.

Samples include postmenopausal women aged 45 to 65 with vaginal atrophy. The sample size is 96 and the duration of the intervention is 12 weeks. Researcher and volunteer Participation in this study is completely unaware from vaginal medications and placebo, and medications tubes fill with pharmacist.Vaginal medications are all in the same package and are coded by the pharmacist. Initially, patients are examined from the symptoms of vaginal atrophy and the questionnaire of mental symptoms of vaginal atrophy is completed by patients. then The vaginal discharge samples are taken for examination of the Vaginal mucosal cell maturation index. The pH of the vagina is also measured by a pH meter. Individuals are randomly assigned to one of three groups. One group (Vaginal Cream, Conjugate estrogen) another group (chamomile vaginal gel) and the control group (placebo vaginal gel) received at a dose of 1 mg for 12 weeks ( First two weeks every night and the next 10 weeks twice a week). End of weeks 2, 6, and 12 are evaluated for signs of vaginal atrophy.at the end of the study, the vaginal pH and vaginal discharge samples are examined.

include criteria: People who have had at least one year of their last menstruation or have a hormonal test with an average fsh> 40 international units There are symptoms of vaginal atrophy The age range is 45-65 years Have sex and monogamy exclude criteria: Vaginal infection needs treatment Genital abnormalities Hormone therapy or use sexual hormones during the 8 weeks prior to the study Using vaginal medicines or any lubricant at least 15 days before the study Tobacco use (alcohol, cigarette and hookah) Breast diseases with unknown cause Uterine bleeding or spotting with unspecified cause Excessive consumption of phytoestrogens such as soy, red clover, fenugreek over the past month BMI more than 30 Cholestatic Diseases of the Liver Severe kidney failure Acute Thrombophlebitis High blood pressure

One group (vaginal cream conjugate estrogen); another group( chamomile vaginal gel) and the control group (placebo vaginal gel)

Treatment of vaginal atrophy; Reducing the complications of vaginal atrophy

Randomized numerical tables using computers. individually

Researcher and volunteer in this study completely unaware of the placebo or medications and medication tubes filled by the pharmacist.Vaginal medications are in the same package and are coded by the pharmacist.