Comparison of the efficacy of Levofloxacin and Clarithromycin in quadruple therapy for the eradication of Helicobacter pylori

Comparison of the efficacy of Levofloxacin and Clarithromycin in quadruple therapy for the eradication of Helicobacter pylori

In this study, 210 patients with peptic ulcer and proven Helicobacter pylori infection referred to the Alzahra Gastrointestinal Hospital will be included in the study and will be randomly assigned to two groups of intervention and control and each participant will be assigned a code.

This study is a randomized clinical trial. Adults with peptic ulcer and proven Helicobacter pylori infection referred to the Alzahra Gastrointestinal Hospital will be included in the study and will be randomly assigned to two groups. The first group is treated with Clarithromycin 500 mg twice daily, Amoxicillin 1 g twice daily, Bismuth 525 mg twice daily, and Pentazole 40 mg twice daily for two weeks. The second group of patients will take levofloxacin 500 mg daily for two weeks instead of clarithromycin. To determine the success of eradication, a stool antigen test will be used at least 4 weeks after the end of the treatment. To assess the severity of symptoms, a short form of the Leeds Dyspepsia Questionnaire at the beginning of the study and the eradication evaluation (4 weeks after the completion of the treatment) will be completed through the interview. To measure the side effects, a standard questionnaire will be completed at the end of the course (day 15) and then at the time of the eradication evaluation (4 weeks after treatment) through the interview. Patient tolerance is measured with five good options, mild intolerance, moderate intolerance, severe intolerance, and forced discontinuation of medication through an interview at the end of the treatment period (day 15). Finally, data analysis is done through SPSS v.16 and Chi-Square, Independent Sample T-Test and MC Nemar tests in both Intention to Treat and Per-Protocol methods.

People over 18 years of age with Helicobacter pylori infection proven without previous history of severe illness, surgery and previous Helicobacter pylori infection

The control group consisted of patients treated with Clarithromycin based on four regimens and the intervention group included patients treated with four drugs based on levofloxacin.

Eradication of Helicobacter Pylori infection Separated drug effects Dyspepsia severity Patient tolerance

Sampling is consecutive. Patients who referred to the gastroenterologist for upper gastrointestinal symptoms and who have had ulcerative peptic ulcer endoscopy and who have been diagnosed with Helicobacter Pylori infection according to a quick test of urease, according to other criteria for entry and absence of study Then, after explaining how the plan is implemented and receiving written consent, patients are randomly assigned (using a random number table generated by Random Allocation Software) into two groups.