Comparison the effect of intranasal Ketamin versus intravenous Morphine on pain in patients with renal colic referring to the Emergency department of Khatam-ol-anbia hospital in Zahedan in 2018

1. Determine the relative mean patients with renal colic in separate groups 2. Determination of the mean pain score at 0, 30 and 60 minutes, based on the VAS scale in the two groups of ketamine and morphine 3. Determination and comparison of mean pain at 0, 5, 30 and 60 minutes, based on the VAS scale in two groups of ketamine and morphine in terms of age 4. Determine and compare the pain at 0, 5, 30, and 60 minutes, based on the VAS scale in the two groups of ketamine and morphine in terms of gender

In this research, 100 patients with renal colic who have entering criteria referred to emergency department of Khatam-ol-Anbia Hospital in two intervention groups are included. Their allocation to the two groups of ketamine and morphine is based on random blocking. Phase 3 of the trial is used in this study.

Renal colic is the cause of a significant proportion of patients in hospital emergency and clinic emergency that is associated with severe pain. Usually, the nature of these pains despite being transient, it is very debilitating and intolerable to the patient. after initial diagnostic evaluations, since most urinary stones recover with anticipated treatment, the most important treatment priority In the acute stage, is to relieve pain. In this research, 100 patients with renal colic who have entering criteria referred to emergency department of Khatam-ol-Anbia Hospital in two intervention groups are included. Their allocation to the two groups of ketamine and morphine is based on random blocking. Phase 3 of the trial is used in this study.

Inclusion criteria: Uncontrollable pain due to renal colic that causes prescribing other painkillers; Not suffering from other underlying disease(Renal- cardiac -liver-DM); age 20-50; No addiction; Not sensitivity to Morphine and ketamine and the lack of pharmaceutical contraindication Exclusion criteria: Pregnant and lactating women; Having blood pressure Dbp <90 and Sbp >80; Nasal congestion; respiratory distress; History of seizure ; History of GLAUCOMA; History of drug abuse

1. Ketamine group: Ketamine will be injected 1 mg per kg into this group patients. 2. Morphine group: Morphine will be injected 0.1mg per kg into this group patients..

pain: will be measured by the vas scale.

After entering randomly blocked patients, patients are divided into two groups that will be matched for pain before medication and age and sex.

Only part of the information, such as the main outcome information, can be shared.

Start the access period 6 months after printing the results

Researchers working in academia

Any use of the data will be subject to the permission of the project owners.

Zahedan University of Medical Sciences

Documentation will be available after confirmation of the administrative request for the use of the project.