Effect of Milrinonein treatment on vasospasm in patients with subarachnoid hemorrhage
Design
This is a Clinical and double-blind clinical trial. 32 candidates for subarachnoid hemorrhage referred to Valiasr Hospital are entered.We will divide patients in two groups randomly.
Settings and conduct
This is a Clinical and double-blind clinical trial. 32 candidates for aneurysms referred to Valiasr Hospital are entered.The patient is not aware of the treatment received.Participant and Analyzer are blind (double blind).An analyzer used to treat a patient don't aware.
Participants/Inclusion and exclusion criteria
inclusion criteria: both of gender, Patients with subarachnoid hemorrhage and vasospasm
Exclusion criteria: Dissatisfaction
Intervention groups
During digital subtraction angiography, we inject 50 micrograms per kilogram melirinone is initially and in following 0.5 to 0.75 micrograms per kilogram per minute melirinone for patients .We compare patients before and after angiography.During digital subtraction angiography, we inject routine drug for patients . It is repeat 10 minutes after angiography injection. We perform by a neurologist TransCranial Doppler sonography in control group.
Main outcome variables
Determine vasoaspasm of the cerebrovascular
General information
Reason for update
Acronym
IRCT registration information
IRCT registration number:IRCT20141209020258N82
Registration date:2018-07-11, 1397/04/20
Registration timing:registered_while_recruiting
Last update:2018-07-11, 1397/04/20
Update count:0
Registration date
2018-07-11, 1397/04/20
Registrant information
Name
Fariba Farokhi
Name of organization / entity
Arak University of Medical Sciences
Country
Iran (Islamic Republic of)
Phone
+98 86 3222 2003
Email address
f.farokhi@arakmu.ac.ir
Recruitment status
Recruitment complete
Funding source
Expected recruitment start date
2017-10-29, 1396/08/07
Expected recruitment end date
2019-10-29, 1398/08/07
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Effect of Milrinonein treatment vasospasm in patients with subarachnoid hemorrhage
Public title
Effect of Milrinonein treatment vasospasm in patients with subarachnoid hemorrhage
Purpose
Treatment
Inclusion/Exclusion criteria
Inclusion criteria:
both of gender
Patients with subarachnoid hemorrhage and vasospasm
Exclusion criteria:
Dissatisfaction
Age
From 30 years old to 80 years old
Gender
Both
Phase
2-3
Groups that have been masked
Participant
Outcome assessor
Data analyser
Sample size
Target sample size:
32
Randomization (investigator's opinion)
Randomized
Randomization description
Randomization with random numbers
Blinding (investigator's opinion)
Double blinded
Blinding description
This study is double-blind. Outcome evaluator and analyzer and participant are blind (double-blind). Outcome evaluator and analyzer don't aware from grouping.
Placebo
Not used
Assignment
Parallel
Other design features
Secondary Ids
empty
Ethics committees
1
Ethics committee
Name of ethics committee
Ethics committee of Arak University Of Medical Sciences
Intervention group: During digital subtraction angiography, we inject 50 micrograms per kilogram melirinone is initially and in following 0.5 to 0.75 micrograms per kilogram per minute melirinone for patients . It is repeat 10 minutes after angiography injection. We perform by a neurologist TransCranial Doppler sonography.
Category
Treatment - Drugs
2
Description
Control group: During digital subtraction angiography, we inject routine drug for patients . It is repeat 10 minutes after angiography injection. We perform by a neurologist TransCranial Doppler sonography.
Category
Treatment - Drugs
Recruitment centers
1
Recruitment center
Name of recruitment center
Valiasr hospital
Full name of responsible person
Dr Mohsen Dalvandi
Street address
Valiasr Hospital, Valiasr square, Shahid Shirodi street