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Study aim
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Comparison of the effect of misoprostol on vaginal, sublingual and buccal methods in induction of labor in term pregnancies.
Comparison of cesarean section among three groups
Comparison of the need for oxytocin in three groups
Comparison of maternal complications among the three groups
Comparison of fetal complications among the three groups
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Design
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Three parallel group, Randomised trial , without blinded
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Settings and conduct
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The study population of this study is women referred to Qazvin Kosar Hospital during the year 2018 who are randomly divided into 3 groups of Misoprostol buccal, sublingual and vaginal. The final sample size is about 100patients per group (300 patients). The data collection is based on the previous checklist. The data are analyzed using SPSS21 software and Kruskal-Wallis analysis, variance tests, mean, and standard deviation were used.
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Participants/Inclusion and exclusion criteria
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The present study will be conducted as a clinical trial. All patients referring to Kowsar Hospital, who had indications of delivery for maternal reasons, included criteria for entering the study, and if they don not have the criteria for exit, they would enter the study after completing the informed consent form. The age of the mother, the gestational age, the BMI of the mother, and the Bishop score in the first visit are recorded by the resident of the gynecologist. The gestational age is determined based on the last menstruation date confirmed by early ultrasonography. Patients are randomly divided into three groups based on randomized method.
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Intervention groups
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the first group, recieved vaginal misoprostol 25 mcg every 6 hours until24 hours, the second group received 50 mcg sublingual misoprostol every 6 hours until24 hours, and the third group received 50 mcg misoprostol buccal every 6 hours until24 hours for induction of labor
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Main outcome variables
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Choosing the best, least expensive, most effective, and least complicated therapies for induction of childbirth