The comparative evaluation of maxillary infiltration and mandibular block injection effect on the cardiovascular parameters with 2 different local anesthesia solutions, Lidocaine and prilocaine in Patients Requiring Restorative Treatment of molar Teeth

The Comparison of maxillary infiltration and mandibular block injection effect on the cardiovascular parameters with 2 different local anesthesia solutions, Lidocaine and prilocaine

Clinical trials with Parallel, Double blind, randomized groups

112 patients referring to the dental school of Kermanshah University of Medical Sciences will be chosen. Patients are randomly divided into four groups, Groups included: 1.Block injection in mandible with 2% lidocaine solution with epinephrine 1: 80,000, 2.infiltration injection in maxilla with lidocaine 2% solution with epinephrine 1: 80,000, 3.Block injection in mandible with prilocaine solution, 4. infiltration injection in maxilla with prilocaine solution. Systolic and diastolic blood pressure and heart rate and blood oxygen saturation percentage will be evaluated, In the four stages. A dark tape will cover each anesthetic cartridge.

Inclusion criteria: People aged 20-50 years, Have general health, needing restorative treatment of maxillary or mandibular molar teeth. Exclusion criteria: medical history of cardiovascular, hypertension, Diabetes, kidney diseases, gastrointestinal bleeding or ulceration, Use of medications that make disturbance in function of anesthetic substance, Patients with pathology problems at the injection site, pregnant and nursing patients

Block injection in mandible with 2% lidocaine solution with epinephrine 1: 80,000, infiltration injection in maxilla with lidocaine 2% solution with epinephrine 1: 80,000, Block injection in mandible with prilocaine 3% solution, infiltration injection in maxilla with prilocaine 3% solution

Level of systolic blood pressure, Level of diastolic blood pressure, Heart rate per minute, Peripheral blood oxygen saturation percentage

Randomization tools are sealed envelopes. Random unit is of individual type. Randomization is a simple way so that numbness cartridges are covered by covers and for each type of numbness we consider one of the numbers 1 and 2 and write the considered number on the cartridges covered with the covers (Each number represents a particular type of anesthetic substance). Then the patient chooses one of these cartridges. These cartridges are provided to patients who visit the Dental Clinics of Kermanshah from May 20, 2018 to June 20, 2018 for restoration of the molar teeth. Placing covers and writing numbers is done only by one of the researchers, so the injector, the evaluator and the participant, are unaware of the type of anesthesia.

Both anesthetics used in the study are safe and do not pose a risk to patients. Before doing the study, written consent is taken from the patients. One of the cartridges covered with a cover that one of the numbers 1 and 2 is written on it, Is selected by the patient (Each number represents a particular type of anesthetic substance). Placing covers and writing numbers is done only by one of the researchers, so the injector, the evaluator and the participant, are unaware of the type of anesthesia.

The comparative evaluation of maxillary infiltration and mandibular block injection effect on the cardiovascular parameters with 2 different local anesthesia solutions, Lidocaine and prilocaine in Patients Requiring Restorative Treatment of molar Teeth

The start of the access period is 6 months after the results are printed

Study data will be available to researchers working in academic and scientific institutions

Access to study data is allowed

Dr Roohollah Sharifi, Faculty Member of Kermanshah University of Medical Sciences Mobile phone: 09122177490

The data can be submitted to Dr. Rouhollah Sharifi by sending an email. r.sharifi@kums.ac.ir