Evaluation of effect of furosemide add on to hypertonic slain on neurohormonal factors in Traumatic brain injury,A randomized single blind clinical trial
This study conducted for the evaluation of hypertonic saline osmotic therapy and added with furosemide in traumatic brain injury’s patients. One group of 30 of the patients will be received 100 ml of hypertonic saline (NaCl 5%) as a loading dose, and then 20ml/h of infusion. Another group of 30 will be received 100 ml of hypertonic saline (NaCl 5%) and 40mg furosemide as a loading dose, and then 20ml/h of NaCl 5% and 0.05mg/kg/ h of furosemide as a 24 h infusion. Evaluation of serum sodium and its osmolarity, changes of S100B and NSE biomarker will be considered as management indicators.
Hormonal alteration (Thyroid and Prolactin) will be concidered as an evaluation of severity of the trauma and the effect of osmotic therapy to reduce hormonal alteration and prolonged function of the patients.
General information
Acronym
IRCT registration information
IRCT registration number:IRCT201509283014N10
Registration date:2016-07-13, 1395/04/23
Registration timing:registered_while_recruiting
Last update:
Update count:0
Registration date
2016-07-13, 1395/04/23
Registrant information
Name
Shahram Ala
Name of organization / entity
Mazandaran University of Medical Sciences
Country
Iran (Islamic Republic of)
Phone
+98 15 1354 3083
Email address
sala@mazums.ac.ir
Recruitment status
Recruitment complete
Funding source
Vice chancellor of research, Mazandaran university of medical sciences
Expected recruitment start date
2016-04-18, 1395/01/30
Expected recruitment end date
2016-09-20, 1395/06/30
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Evaluation of effect of furosemide add on to hypertonic slain on neurohormonal factors in Traumatic brain injury,A randomized single blind clinical trial
Public title
Evaluation of effect of furosemide add on to hypertonic slain on neurohormonal factors in Traumatic brain injury
Purpose
Treatment
Inclusion/Exclusion criteria
Inclusion criteria: All of patients with 18-90 years old with closed head trauma ; associated with brain edema confirmed with CT scan
; Hemodynamically stable before management; GCS<14; Patients with CV line
; admission with in 24 hours of initial insult