Effect of Six Weeks High Intensity Intermittent Training With and Without Turmeric Supplementation on Irisin, Thermogenin (UCP1) and visceral Fat in Obese Females
Effect of High Intensity Intermittent Training With and Without Turmeric Supplementation on Irisin, Thermogenin (UCP1) and visceral Fat in Obese Females
Design
Clinical trial with pre test- post test pattern, The goal of prevention, parallel groups, double blind, Sample size of 30 people in two groups (15 people in each group)
Settings and conduct
Coordination meetings, Initial measurements, Advice, Distribution of capsules and Exercises will be held at the persian Gulf club in Ayatollah Yektaei street. Blood sampling will be taken in Khalkhal Social Security Laboratory. Researcher and participants blinding for plasebo and turmeric capsuls will be done by third person.
Participants/Inclusion and exclusion criteria
Inclusion criteria: females aged 20 to 25 years old, obesity ( Body Mass Index equal and greater than 30), Not having regular exercise training, not using drug and supplement.
Exclusion criteria: Having disease ,Allergy to spices, Unwillingness to cooperate with the researcher
Intervention groups
Exercise group: 3 weeks preparation training (50 to 80 percent Heart Rate Reserve(HRR)) and 6 weeks High Intensity Intermittent Training (HIIT) (80 to 100 percent HRR). 4 session per week.
Exercise and Supplement group: The above-mentioned protocol In addition Turmeric supplementation ( 3 milligram Curcumin per kilogram body weight per day)
Main outcome variables
Plasma Irisin, Thermogenin (UCP1) and visceral Fat Diameter
General information
Reason for update
Acronym
IRCT registration information
IRCT registration number:IRCT20180317039120N1
Registration date:2018-04-25, 1397/02/05
Registration timing:registered_while_recruiting
Last update:2018-04-25, 1397/02/05
Update count:0
Registration date
2018-04-25, 1397/02/05
Registrant information
Name
Zahra Rostami Hashjin
Name of organization / entity
Tabriz University
Country
Iran (Islamic Republic of)
Phone
+98 41 3334 0081
Email address
zahra.rostami.h@tabrizu.ac.ir
Recruitment status
Recruitment complete
Funding source
Expected recruitment start date
2018-04-09, 1397/01/20
Expected recruitment end date
2018-05-10, 1397/02/20
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Effect of Six Weeks High Intensity Intermittent Training With and Without Turmeric Supplementation on Irisin, Thermogenin (UCP1) and visceral Fat in Obese Females
Public title
Effect of high intensity Training and Turmeric on Obesity
Purpose
Prevention
Inclusion/Exclusion criteria
Inclusion criteria:
Having a BMI equal and greater than 30
Not having Special disease history and drug consumption ( be healthy)
Age range 20 to 25 years old
Exclusion criteria:
performing regular exercise training during last 6 month
Allergy to spices
Unwillingness to cooperate with the researcher
Age
From 20 years old to 25 years old
Gender
Female
Phase
N/A
Groups that have been masked
No information
Sample size
Target sample size:
30
Randomization (investigator's opinion)
Randomized
Randomization description
Using random numbers table, individuals will grouped into two groups
Blinding (investigator's opinion)
Not blinded
Blinding description
Placebo
Used
Assignment
Parallel
Other design features
Secondary Ids
empty
Ethics committees
1
Ethics committee
Name of ethics committee
Ethics committee of Tabriz University of Medical Sciences
Street address
Research Vice-Chancellor, Third ّfloor, Central Building No. 2, Tabriz University of Medical Sciences, Golgasht Ave
City
Tabriz
Province
East Azarbaijan
Postal code
5166616471
Approval date
2018-03-12, 1396/12/21
Ethics committee reference number
IR.TBZMED.REC.1396.1297
Health conditions studied
1
Description of health condition studied
Obesity
ICD-10 code
E66.9
ICD-10 code description
Obesity, unspecified
Primary outcomes
1
Description
Plasma Irisin Levels
Timepoint
Before Intervention and 48 hours after last intervention session
Method of measurement
ELISA Method
2
Description
Plasma UnCoupling protein 1 (UCP1) Levels
Timepoint
Before Intervention and 48 hours after last intervention session
Method of measurement
ELISA Method
3
Description
Visceral Fat Diameter
Timepoint
Before and After Training Intervention
Method of measurement
Ultrasound Method
Secondary outcomes
1
Description
Body composition indicators
Timepoint
Before and After Intervention
Method of measurement
Body mass index, Waist–hip ratio, Body Fat - Jackson/Pollock 3-Site Caliper Method tool